Kinase-linked receptors

Kinase-linked receptors (KLRs) are one of the main cell surface receptors that function similar to other transmembrane receptors. They are an important pathway in term of messages transduction which mediate cells to communicate with each other. Kinase-linked receptors work as a gatekeeper of a company. They receive information, controls the access and then instructs people to do specific things. Kinase-linked receptors utilise a comparable process in order to deliver suitable tasks to the cells. Signals received from the environment, enter the cells and then KLRs command the cells to do certain jobs. Enzyme linked receptors are a type of integral membrane proteins that have an unparalleled feature as they act like enzymes as well as receiving messages from chemical messengers. In our body there is a substance called enzymes which act as a catalyst or an accelerator. Enzymes play an essential role in speeding up the chemical process that occur within the living organisms and cells.

 

Their work and structure:

Kinase linked receptors (KLRS) play an important role in protein phosphorylation, gene transcription, protein synthesis and cellular effect. The structure of KLRs is shaped similar to tuning fork (¡). The top of the fork (the receptor) is a biding domain, this place is where the ligand can bind. At the bottom of the fork is a catalytic domain, that region is where the speed up reaction take place. This unique structure facilitates the process of converting a message from outside the cell to a structural change within the cell.

 

The three main types:

Kinase linked receptor is regarded as considerable and heterogeneous family of membrane surface receptors. This group can be divided into three main subclasses according to their speed up reaction.

 

 

Receptor tyrosine kinases:

Receptor tyrosine kinases RTKs are one of the essential subclass of kinase linked receptors. It functions as toggle switches in most living cells’ function. RTKs are enzymes that have the ability to transfer phosphate group from cell’s fuel which is ATP to tyrosine residue in a protein.

 

Receptor tyrosine kinases mechanism:

 

 

drug in current use that acts on Receptor tyrosine kinases