The Villian that helps our bodies? Agonists and Antagonists (Rough Draft)

When we refer to antagonists and agonists, no, we are not talking about movie villains trying to eradicate half of the universe’s population, instead we are talking about drugs that interact with our body receptors.

Agonist and Antagonists; discuss the key differences between the two.

An agonist is a drug that binds to the receptor, producing a similar response to the intended chemical and receptor. Whereas an antagonist is a drug that binds to the receptor either on the primary site, or on another site, which all together stops the receptor from producing a response.

The main difference between these two drugs is that one simulates the intended reaction, where as an antagonist binds to the receptor, and stops/ slows responses. Agonists essentially mimic the activities of normal neurotransmitters such as Acetylcholine, and emulate a similar response from the receptors they bind to. A great analogy to think of is with a vending machine. Usually to buy a drink, you would insert a $1 coin into the machine, and the response is for it to spit out your favourite soda. An agonist in this scenario would be to use a metal disc, of the same size as a coin to insert into the machine, thus using the same coin slot with a mimic coin to obtain a soda.

An antagonist does the opposite of an agonist. It binds to receptors, and stops the receptor from producing a desired response. Going back to the analogy, it’s like jamming the machine’s coin slot so that it is unable to perform its function until the blockage is removed.

–Choose an antagonist, discuss primary inhibitory mechanism and explain in detail how this relates to the way in which it interacts with receptors.– [subject brief as I may change if I can find a more interesting antagonist]

Atropine is a reversible, competitive antagonist of the receptor muscarinic acetylcholine receptors, in language that you and I can understand, it is a removable coin blocker for a vending machine that controls some of our bodily functions, such salivation and heart rate. [image of lock and key-esque model]

Atropine inhibits some of the functions of the parasympathetic system, so it effects things such as heart rate, salivation and pupil dilation. Atropine is used to treat bradycardia, that is slowed heart rate, in patients, and is also used to lower the amount of saliva produced in some specific surgeries.

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    – **Antagonists**, however, interfere by blocking the receptor or binding to it in a way that prevents the usual response, much like jamming the coin slot so the machine can’t work.

    #### Agonists: Mimicking the Body’s Response

    Agonists are like an imposter that tricks the body into reacting as if the natural chemical is at work. A great analogy is a vending machine: normally, you’d insert a dollar coin, and the machine gives you a soda. Now imagine you use a similar-looking metal disc (the agonist) that fits perfectly into the coin slot. It still triggers the machine to deliver your soda, just like the original coin would.

    The body has neurotransmitters—like **acetylcholine**—that naturally fit into specific receptors. When an agonist comes along, it mimics these neurotransmitters, triggering a similar response. For example, drugs that act as agonists for acetylcholine receptors can cause effects like increased salivation or even regulate heart rate.

    #### Antagonists: Blocking the Action

    Now, let’s look at the **antagonist**, which does the opposite. Instead of helping, it hinders. The antagonist binds to a receptor but prevents it from producing a response, either by blocking the primary site or by binding elsewhere to cause interference. Going back to the vending machine, an antagonist is like putting a piece of paper in the coin slot to block it. No matter how hard you try, the machine can’t process the coin and won’t give you a soda until you remove the blockage.

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    Atropine is used to treat **bradycardia** (slow heart rate), and it also reduces saliva production in certain surgeries. It works by preventing the parasympathetic system—the part of the nervous system that controls things like heart rate and digestion—from doing its job. When atropine blocks the receptors, the body’s usual responses don’t occur, which can be helpful in specific medical situations.

    ### Conclusion

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  • **Reflecting on Today: A Brief Diary Entry**

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  • Today’s Reflection: A Short Diary Entry

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