The Villian that helps our bodies? Agonists and Antagonists (Rough Draft)

When we refer to antagonists and agonists, no, we are not talking about movie villains trying to eradicate half of the universe’s population, instead we are talking about drugs that interact with our body receptors.

Agonist and Antagonists; discuss the key differences between the two.

An agonist is a drug that binds to the receptor, producing a similar response to the intended chemical and receptor. Whereas an antagonist is a drug that binds to the receptor either on the primary site, or on another site, which all together stops the receptor from producing a response.

The main difference between these two drugs is that one simulates the intended reaction, where as an antagonist binds to the receptor, and stops/ slows responses. Agonists essentially mimic the activities of normal neurotransmitters such as Acetylcholine, and emulate a similar response from the receptors they bind to. A great analogy to think of is with a vending machine. Usually to buy a drink, you would insert a $1 coin into the machine, and the response is for it to spit out your favourite soda. An agonist in this scenario would be to use a metal disc, of the same size as a coin to insert into the machine, thus using the same coin slot with a mimic coin to obtain a soda.

An antagonist does the opposite of an agonist. It binds to receptors, and stops the receptor from producing a desired response. Going back to the analogy, it’s like jamming the machine’s coin slot so that it is unable to perform its function until the blockage is removed.

–Choose an antagonist, discuss primary inhibitory mechanism and explain in detail how this relates to the way in which it interacts with receptors.– [subject brief as I may change if I can find a more interesting antagonist]

Atropine is a reversible, competitive antagonist of the receptor muscarinic acetylcholine receptors, in language that you and I can understand, it is a removable coin blocker for a vending machine that controls some of our bodily functions, such salivation and heart rate. [image of lock and key-esque model]

Atropine inhibits some of the functions of the parasympathetic system, so it effects things such as heart rate, salivation and pupil dilation. Atropine is used to treat bradycardia, that is slowed heart rate, in patients, and is also used to lower the amount of saliva produced in some specific surgeries.

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  • Consider adding diagrams to demonstrate reversible competitive, irreversible competitive, and non-competitive types of antagonism. Additionally, improve the layout for better reader engagement, and remember to include in-text referencing. Read More

  • Engaging title! Consider adding reversible competitive, irreversible competitive and non-competitive types of antagonism. Use diagrams for demonstration. Improve layout for reader engagement. Remember to include in-text referencing. Read More

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  • Loved the analogies and the content was very engaging. Just needs to be placed in a blog format, which I am sure you will do. Referencing would be ideal throughout the text. Great work!

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  • So if someone refers to themselves as an agonist are they really trying to say that, if needed , they are flexible or able to change into something which they are not in order to satisfy someone’s needs , wants etc

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  • Really Loved 😍the analogies and the content was very engaging. Just needs to be placed in a blog format, PDF format or other format alike which I am very sure you will do that. Referencing would be involve, for research purposes. I really appreciated. Great work!!!💪👍👍

  • Good stuff mate
    Although putting on a PDF should grant a few easy marks as it makes it look more presentable but I’m pretty sure you’re way ahead of that. In terms of content wise, great engaging language and I think just like you mentioned to add diagrams seems like a great idea. Keep one rocking bro
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  • Excellent analogy to introduce topic, good flow of content, easy to follow on with analogies to aid in understanding concepts. Obviously as a rough draft, this hasn’t got much but excellent start!

  • Hey Andrew,
    As your colleagues have suggested, this needs to be updated to a blog format as a pdf for example. You’ll also need more figures/ emphasis on headings.
    I like how you’ve kept the same analogy throughout! It works well.
    Your current examples, when expanded will also be good.

  • Hey Andrew! This is reading so well! You have created a fantastic conversational style tone and used some wonderful analogies to try and limit the scientific jargon used which means that someone with no prior knowledge can understand your document really well! It was great to read and is very engaging and interesting for the audience. Make sure to include some colourful diagrams in the final product. Remember to include a reference list. Looking great 🙂

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  • Very engaging title! I like the use of your vending machine analogy. However, I do think you should also include the different types of anatongonism: reversible competitive, irreversible competitive and non-competitive. There will be plenty of diagrams online to demonstrate these also!

    I do suggest in your final submission to improve your layout for reader engagement. Also remember that you will be required to have in text referencing throughout!

  • Really easy to understand article and the the analogies used are really helpful and add value to the overall content. You’ve mentioned throughout that you’re yet to add diagrams which will definitely help add to your blog. The only thing I would say is to maybe reconsider the formatting. Colours, fonts and different sized text break up the wordiness and help the audience engage better 🙂

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